Successful Treatment of Intralesional Bleomycin in Keloids of Vietnamese Population

• Published in: Open access Macedonian journal of medical sciences Vol. 7; no. 2; pp. 298 - 299
• Main Authors: Huu, Nghi Dinh, Huu, Sau Nguyen, Thi, Xuan Le, Van, Thuong Nguyen, Minh, Phuong Pham Thi, Minh, Trang Trinh, Van, Tam Hoang, Cam, Van Tran, Huyen, My Le, Hau, Khang Tran, Gandolfi, Marco, Satolli, Francesca, Feliciani, Claudio, Tirant, Michael, Vojvodic, Aleksandra, Lotti, Torello
• Format: Journal Article
• Language: English
• Published: Macedonia Republic of Macedonia 30.01.2019
• Subjects: Clinical Science; Keloid; Bleomycin
• ISSN: 1857-9655; 1857-9655
• DOI: 10.3889/oamjms.2019.099

Keloid is an overactive condition of the skin tissue to early lesions characterised by proliferation of fibroblasts, excessive collagen production in the lesion. Treatment of keloids is a big challenge because of the poor response rate and high risk of recurrence after treatment. We found that bleomycin offers promise in the treatment of keloids. To evaluate the efficacy of bleomycin injected in the injury for keloids treatment. The treatment was carried out in 55 patients having 120 keloids of different sizes and locations. Average treatments were 4 times. Complete flattening was 70.8%, highly significant flattening was 8.3%, no patient of minimal flattening. Systemic side-effects of bleomycin were not evaluated, but local side-effects were mainly pains (100%), blisters (78.3%), ulceration (5.8%), and hyperpigmentation (56.7%). The percentage of patients recurring 6, 12, 15, 18 months after the last treatment were 3.8, 15.4, 45.5, 50%, respectively.