Efficacy of Oral Isotretinoin in Combination with Desloratadine in the Treatment of Common Vulgaris Acne in Vietnamese Patients

• Published in: Open access Macedonian journal of medical sciences Vol. 7; no. 2; pp. 217 - 220
• Main Authors: Van, Thuong Nguyen, Thi, Lan Duong, Trong, Hao Nguyen, Van, Tro Chau, Minh, Trang Trinh, Minh, Phuong Pham Thi, Huu, Nghi Dinh, Cam, Van Tran, Huyen, My Le, Hau, Khang Tran, Gandolfi, Marco, Satolli, Francesca, Feliciani, Claudio, Tirant, Michael, Vojvodic, Aleksandra, Lotti, Torello
• Format: Journal Article
• Language: English
• Published: Macedonia Republic of Macedonia 30.01.2019
• Subjects: Clinical Science; Common acne; Isotretinoin; Desloratadine
• ISSN: 1857-9655; 1857-9655
• DOI: 10.3889/oamjms.2019.054

To evaluate the efficacy of oral isotretinoin used alone and in combination with desloratadine in the treatment of moderate acne vulgaris. A comparative clinical trial was undertaken to evaluate the efficacy of oral isotretinoin alone and in combination with desloratadine in the treatment of 62 moderate acne vulgaris patients. Patients were randomised into two groups with 31 patients in each group. Each studied group's patient took 20 mg isotretinoin and 5 mg desloratadine per day. In the control group, patients took only 20 mg isotretinoin per day. The treatment time was 16 weeks. The evaluation and follow-up were done at week 2, 4, 8, 12 and 16 of the treatment. The studied group had a better curative rate than the control group (45.2% versus 22.6%). The average number of inflammatory lesions in the studied group was significantly lower than the control group (0.19 versus 0.94). The mean GAGS score of the studied group was significantly lower than the control group (3.71 versus 6.52). Acne outbreaks rate of the studied group was lower than the control group (in week 2: 22.6% versus 45.2% and in week 4: 16.1% versus 38.7%, respectively). The rate of itchy was lower in the studied group. In the treatment of moderate acne vulgaris, oral isotretinoin in combination with desloratadine is more effective and has fewer side effects than using isotretinoin alone.