The Role of Serial NT-ProBNP Level in Prognosis and Follow-Up Treatment of Acute Heart Failure after Coronary Artery Bypass Graft Surgery

• Published in: Open access Macedonian journal of medical sciences Vol. 7; no. 24; pp. 4411 - 4415
• Main Authors: Thanh, Bui Duc, Son, Nguyen Hong, Pho, Dinh Cong, Bac, Nguyen Duy, Nga, Vu Thi, Dung, Quan Anh, Anh, Do Duc, Linh, Do Dieu, Viet, Hoang Thi Bich, Anh, Bui Dang The, Tan, Ha The, Hung, Pham Ngoc
• Format: Journal Article
• Language: English
• Published: North Macedonia Republic of Macedonia 30.12.2019
• Subjects: Basic and Clinical Medical Researches in Vietnam; coronary artery bypass graft surgery (CABG); N-terminal pro-B-type natriuretic peptide (NT-proBNP); prognosis; serial measurements; acute heart failure (AHF); follow-up treatment
• ISSN: 1857-9655; 1857-9655
• DOI: 10.3889/oamjms.2019.872

After coronary artery bypass graft (CABG) surgery, heart failure is still major problem. The valuable marker for it is needed. Evaluating the role of serial NT-proBNP level in prognosis and follow-up treatment of acute heart failure after CABG surgery. The prospective, analytic study evaluated 107 patients undergoing CABG surgery at Ho Chi Minh Heart Institute from October 2012 to June 2014. Collecting data was done at pre- and post-operative days with measuring NT-proBNP levels on the day before operation, 2 hours after surgery, every next 24 h until the 5 day, and in case of acute heart failure occurred after surgery. On the first postoperative day (POD1), the NT-proBNP level demonstrated significant value for AHF with the cut-off point = 817.8 pg/mL and AUC = 0.806. On the second and third postoperative day, the AUC value of NT- was 0.753 and 0.751. It was statistically significant in acute heart failure group almost at POD 1 and POD 2 when analyzed by the doses of dobutamine, noradrenaline, and adrenaline (both low doses and normal doses). Serial measurement of NT-proBNP level provides useful prognostic and follow-up treatment information in acute heart failure after CABG surgery.