Acute gastric erosions in the rat. I. Microangiography

Microangiography of the gastric mucosa was performed in 16 adult rats 5 hours after administration of indomethacin. Superficial gastric erosions were induced irrespective of the route of administration. Microangiography demonstrated absence of vascular dilatation underneath the superficial gastric e...

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Bibliographic Details
Published inActa radiologica. Oncology Vol. 20; no. 5; p. 345
Main Authors Rubio, C A, Kollberg, B, Johansson, C, Rodensjö, M
Format Journal Article
LanguageEnglish
Published Sweden 1981
Subjects
Angiography
Animals
Gastric Mucosa - blood supply
Gastric Mucosa - drug effects
Gastric Mucosa - pathology
Indomethacin - pharmacology
Ischemia - chemically induced
Male
Microcirculation - diagnostic imaging
Microcirculation - drug effects
Necrosis
Rats
Rats, Inbred Strains
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Summary:Microangiography of the gastric mucosa was performed in 16 adult rats 5 hours after administration of indomethacin. Superficial gastric erosions were induced irrespective of the route of administration. Microangiography demonstrated absence of vascular dilatation underneath the superficial gastric erosions, suggesting absence of protracted vascular spasm or microthrombosis in eroded areas. The presence of normal microangiographic appearances underneath the gastric erosions suggests that such lesions may be induced by mechanisms other than by vascular injury.
ISSN:0349-652X
DOI:10.3109/02841868109130220