4. Age dependence of the multiplicity of Plasmodium falciparum infections and of other malariological indices in an area of high endemicity
The relationship between age and various malariological indices in the Kilombero valley of Tanzania were examined by compiling data from 6 different community studies carried out between 1989 and 1996. The rate of acquisition of Plasmodium falciparum infection was highest in children 1–5 years of ag...
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Published in | Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 93; no. Supplement-1; pp. 15 - 20 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.02.1999
Royal Society of Tropical Medicine and Hygiene |
Subjects | |
Online Access | Get full text |
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Summary: | The relationship between age and various malariological indices in the Kilombero valley of Tanzania were examined by compiling data from 6 different community studies carried out between 1989 and 1996. The rate of acquisition of
Plasmodium falciparum infection was highest in children 1–5 years of age, while recovery rates were lowest between the first birthday and early adolescence. As a result, peak prevalence was reached in 3–5 years old children. However, the prevalence of clinical malaria (estimated from the excess risk of axillary temperatures ≥37·5 °C attributable to parasitaemia) was highest in children under one year of age. The peak in multiplicity of infection (identified by polymerase chain reaction-restriction fragment length polymorphism of the
msp2 locus) occurred in 3–7 years old children. There was a significant correlation between parasite density and multiplicity of infection in infants and young children (1–2 years of age) but not in older individuals. |
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Bibliography: | istex:8B09695D72CEA413A22DE3BDB686F03DBB6499E2 ark:/67375/HXZ-Q7G49XSP-T Current address: ward-adrao, 01 B.P. 2551 Bouaké, Côte d'Ivoire. |
ISSN: | 0035-9203 1878-3503 |
DOI: | 10.1016/S0035-9203(99)90322-X |