The cytochrome P-450 catalyzed oxidation of 1-methylcyclohexene. Competition between hydroxylation and epoxidation and absolute stereochemistry of the epoxidation

The title reaction gives allylic hydroxylation and epoxidation products in about 2:1 ratio, 1-methyl-1,2-epoxycyclohexane being formed with a 46% e.e. of the (1R,2S) enantiomer. The title reaction gives products 2–10. Allylic hydroxylation and epoxidation products are in 2:1 ratio, 2 being formed wi...

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Published inBioorganic & medicinal chemistry letters Vol. 1; no. 2; pp. 121 - 124
Main Authors Bellucci, Giuseppe, Chiappe, Cinzia, Marioni, Franco, Gervasi, Pier Giovanni, Lippi, Annalisa
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 1991
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Summary:The title reaction gives allylic hydroxylation and epoxidation products in about 2:1 ratio, 1-methyl-1,2-epoxycyclohexane being formed with a 46% e.e. of the (1R,2S) enantiomer. The title reaction gives products 2–10. Allylic hydroxylation and epoxidation products are in 2:1 ratio, 2 being formed with a 46% e.e. of the (1R,2S) enantiomer.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)80244-9