Partially halogenated heterocycles. Synthesis of 5,7-difluoro, 5,6,7-trifluoro and 7-chloro-6,8-difluoroquinolines

3,5-Difluoro,3,4,5-trifluoro- and 3-chloro-2,4-difluoroanilines react in modified Skraup condensations to produce the corresponding fluorinated quinolines in high yields.

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Bibliographic Details
Published inJournal of fluorine chemistry Vol. 91; no. 1; pp. 25 - 26
Main Authors Oleynik, Ivan I., Shteingarts, Vitalii D.
Format Journal Article
LanguageEnglish
Published LAUSANNE Elsevier B.V 10.08.1998
Elsevier
Subjects
5,6,7-Trifluoroquinoline
5,7-Difluoroquinoline
7-Chloro-6,8-difluoroquinoline
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
m-Nitrobenzenesulfonic acid
Physical Sciences
Science & Technology
Skraup reaction
Skraup reaction
7-Chloro-6,8-difluoroquinoline
5,6,7-Trifluoroquinoline
m-Nitrobenzenesulfonic acid
5,7-Difluoroquinoline
m-nitrobenzenesulfonic acid
7-chloro-6,8-difluoroquinoline
5,7-difluoroquinoline
5,6,7-trifluoroquinoline
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Summary:3,5-Difluoro,3,4,5-trifluoro- and 3-chloro-2,4-difluoroanilines react in modified Skraup condensations to produce the corresponding fluorinated quinolines in high yields.
ISSN:0022-1139
1873-3328
DOI:10.1016/S0022-1139(98)00195-X