Monitoring the solid phase synthesis of analogues of lysobactin and the katanosins using in situ MALDI-TOF MS

A method of solid phase reaction analysis is described using an in situ cleavage process (TFA vapour) followed by MALDI-TOF MS analysis. The process is demonstrated by the solid phase synthesis of a depsipeptide based on the antibiotic Lysobactin. A method of solid phase reaction analysis using MALD...

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Bibliographic Details
Published inTetrahedron Vol. 53; no. 41; pp. 14021 - 14030
Main Authors Egner, Bryan J., Bradley, Mark
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 13.10.1997
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PEPTIDE-SYNTHESIS
COMBINATORIAL CHEMISTRY
AMINO-ACIDS
MASS-SPECTROMETRY
RESOLUTION
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Summary:A method of solid phase reaction analysis is described using an in situ cleavage process (TFA vapour) followed by MALDI-TOF MS analysis. The process is demonstrated by the solid phase synthesis of a depsipeptide based on the antibiotic Lysobactin. A method of solid phase reaction analysis using MALDI-TOF MS is illustrated by the synthesis of a depsipeptide template.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(97)00907-1