Role of Cholinergic Mossy Fibers in Vestibular Nuclei in the Development of Vestibular Compensation

Several lines of evidence have suggested that acetylcholine is a possible neurotransmitter/neuromodulator involved in vestibular compensation. However, details of cholinergic effective sites during vestibular compensation remain unclear. In this study, we selectively damaged the rat vestibulo-floccu...

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Bibliographic Details
Published inActa oto-laryngologica Vol. 121; no. 542; pp. 101 - 104
Main Author Kitahara, M. Fukushima, N. Takeda, T. Saika, A. Uno, T. Kubo, T.
Format Journal Article
LanguageEnglish
Published Informa UK Ltd 2001
Taylor & Francis
Subjects
Acetylcholine Ethylcholine Mustard Aziridinium Fluoro Gold Dye Flocculus Labyrinthectomy
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Summary:Several lines of evidence have suggested that acetylcholine is a possible neurotransmitter/neuromodulator involved in vestibular compensation. However, details of cholinergic effective sites during vestibular compensation remain unclear. In this study, we selectively damaged the rat vestibulo-floccular cholinergic mossy fibers using ethylcholine mustard aziridinium ion. In these animals, unilateral labyrinthectomy caused more severe vestibulo-ocular deficits, especially in the initial stage. These findings suggest that the vestibulo-floccular cholinergic mossy fibers serve to restore the balance between intervestibular nuclear activities in order to induce vestibular compensation in the initial stage.
ISSN:0001-6489
1651-2251
DOI:10.1080/000164801750388234