Exercise Is an Adjuvant to Contemporary Dystrophy Treatments

Duchenne muscular dystrophy is a lethal genetic disease of muscle wasting for which there is no cure. In healthy muscle, structure and function improve dramatically with exercise. In patients with dystrophy, little is known about the effects of exercise. As contemporary therapies rapidly progress an...

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Bibliographic Details
Published inExercise and sport sciences reviews Vol. 46; no. 1; p. 34
Main Authors Kostek, Matthew C, Gordon, Bradley
Format Journal Article
LanguageEnglish
Published United States 01.01.2018
Subjects
Animals
Combined Modality Therapy
Energy Metabolism - physiology
Exercise Therapy - adverse effects
Exercise Therapy - methods
Genetic Therapy - methods
Humans
Inflammation - physiopathology
Mitochondria, Muscle - physiology
Muscle, Skeletal - physiopathology
Muscular Dystrophy, Duchenne - physiopathology
Muscular Dystrophy, Duchenne - therapy
Oxidative Stress - physiology
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Summary:Duchenne muscular dystrophy is a lethal genetic disease of muscle wasting for which there is no cure. In healthy muscle, structure and function improve dramatically with exercise. In patients with dystrophy, little is known about the effects of exercise. As contemporary therapies rapidly progress and patients become more active, there is a need to understand the effects of exercise.
ISSN:1538-3008
DOI:10.1249/JES.0000000000000131