APPLICATION OF THE VICINAL OXYAMINATION REACTION WITH ASYMMETRIC INDUCTION TO THE HEMISYNTHESIS OF TAXOL AND ANALOGS

Taxol, 10-deacetyl taxol and their related side chain analogues can be obtained via a "Sharpless'' oxyamination reaction on 13-cinnamoyl baccatin III. Asymmetric induction has been studied using different bridgehead amines as chiral ligands. This procedure constitutes an alternative r...

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Bibliographic Details
Published inTetrahedron Vol. 45; no. 13; pp. 4177 - 4190
Main Authors MANGATAL, L, ADELINE, MT, GUENARD, D, GUERITTEVOEGELEIN, F, POTIER, P
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.01.1989
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:Taxol, 10-deacetyl taxol and their related side chain analogues can be obtained via a "Sharpless'' oxyamination reaction on 13-cinnamoyl baccatin III. Asymmetric induction has been studied using different bridgehead amines as chiral ligands. This procedure constitutes an alternative route to taxol derivatives for biological studies.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(01)81313-2