Reaction of aziridinium ions with organometallic reagents: optimization of the key step of ecopipam synthesis

Formation, stability and reactivity of aziridinium ions 3 towards organometallic reagents was explored and optimized for the efficient preparation of key drug intermediate 5c . Formation, stability and reactivity of aziridinium ions 3 towards organometallic reagents was explored and optimized for th...

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Bibliographic Details
Published inTetrahedron letters Vol. 43; no. 35; pp. 6121 - 6125
Main Authors Andrews, David R, Dahanukar, Vilas H, Eckert, Jeffrey M, Gala, Dinesh, Lucas, Brian S, Schumacher, Doris P, Zavialov, Ilia A
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 26.08.2002
Elsevier
Subjects
aziridines
aziridinium ions
Chemistry
Chemistry, Organic
electron affinity
Grignard reagents
Physical Sciences
Science & Technology
SET mechanism
aziridines
SET mechanism
Grignard reagents
aziridinium ions
electron affinity
REARRANGEMENT
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Summary:Formation, stability and reactivity of aziridinium ions 3 towards organometallic reagents was explored and optimized for the efficient preparation of key drug intermediate 5c . Formation, stability and reactivity of aziridinium ions 3 towards organometallic reagents was explored and optimized for the efficient preparation of key drug intermediate 5c .
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(02)01337-0