A systematic synthetic approach to phosphinophenyl-glycine and -alanine chiral phosphine ligands with amino acid moieties

ortho- and para-phosphinophenyl derivatives of glycine and alanine have been synthesised by nucleophilic phosphination of 2- and 4-fluorophenylglycine and -alanine with Ph(R)PK (R = Me, Ph). The structure of 2-diphenylphosphino-α-phenylglycine has been identified by X-ray analysis. Phosphinophenyl d...

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Bibliographic Details
Published inTetrahedron letters Vol. 38; no. 13; pp. 2257 - 2258
Main Authors Tepper, Michael, Stelzer, Othmar, Häusler, Thomas, Sheldrick, William S.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 31.03.1997
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PHENYLGLYCINE DERIVATIVES
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Summary:ortho- and para-phosphinophenyl derivatives of glycine and alanine have been synthesised by nucleophilic phosphination of 2- and 4-fluorophenylglycine and -alanine with Ph(R)PK (R = Me, Ph). The structure of 2-diphenylphosphino-α-phenylglycine has been identified by X-ray analysis. Phosphinophenyl derivatives of glycine and alanine have been obtained by nucleophilic phosphination of fluorophenylglycine and alanine with potassium phosphides Ph(R)PK (R = Me, Ph).
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(97)00335-3