The design and biological evaluation of a series of 3-hydroxy-3-methylglutaryl coenzyme a (HMG-CoA) reductase inhibitors related to dihydromevinolin

• Published in: Bioorganic & medicinal chemistry letters Vol. 2; no. 3; pp. 223 - 228
• Main Authors: Bone, Elisabeth A., Cunningham, Emer M., Davidson, Alan H., Galloway, W.Alan, Lewis, Christopher N., Morrice, Elizabeth M., Reeve, Maxwell M., Todd, Richard S., White, Ingrid M.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 1992
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/S0960-894X(01)81069-6

HMG-CoA reductase inhibitors structurally related to dihydromevinolin have been designed and tested. It has been shown that for high inhibitory potency these compounds must possess a methyl group at the C-7 position, but several different alkenes can be tolerated at the C-3 position. These compounds show good activity both in vitro and in vivo . HMG-CoA reductase inhibitors structurally related to dihydromevinolin have been designed and tested. It has been shown that for high inhibitory potency these compounds must possess a methyl group at the C-7 position, but several different alkenes can be tolerated at the C-3 position. These compounds show good activity both in vitro and in vivo .