A new convenient route to radioiodinated N-succinimidyl 3- and 4-iodobenzoate, two reagents for radioiodination of proteins

A straightforward method for the synthesis of N-succinimidyl 3- and 4-[ 124I]iodobenzoate ( m- and p-[ 124I]SIB) via destannylation has been developed. The stannylated precursor was obtained as a white crystalline solid in 80% overall yield from 3- or 4-iodobenzoic acid after a two step synthesis. I...

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Bibliographic Details
Published inApplied radiation and isotopes Vol. 49; no. 8; pp. 955 - 959
Main Authors Koziorowski, J, Henssen, C, Weinreich, R
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.08.1998
Elsevier
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Life Sciences & Biomedicine
Nuclear Science & Technology
Physical Sciences
Radiology, Nuclear Medicine & Medical Imaging
Science & Technology
Technology
I-124
RADIOIMMUNOTHERAPY
POSITRON EMISSION TOMOGRAPHY
TUMOR
IODOBENZOATE
LABEL
INVIVO STABILITY
MONOCLONAL-ANTIBODIES
CANCER
RADIOHALOGENATION
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Summary:A straightforward method for the synthesis of N-succinimidyl 3- and 4-[ 124I]iodobenzoate ( m- and p-[ 124I]SIB) via destannylation has been developed. The stannylated precursor was obtained as a white crystalline solid in 80% overall yield from 3- or 4-iodobenzoic acid after a two step synthesis. Iododestannylation was performed with 4.2-d (25% β +) 124I and Iodogen or Iodobeads as the oxidant yielding 90% of the desired product.
ISSN:0969-8043
1872-9800
DOI:10.1016/S0969-8043(97)10112-9