Neonatal Soft Tissue Reconstruction Using a Bioengineered Skin Substitute

Total parenteral nutrition (TPN) can be a lifesaving intervention for premature neonates and it is often delivered through peripheral access in this unique population. However, extravasation and tissue damage can result. Current literature lacks strong evidence regarding the treatment and reconstruc...

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Bibliographic Details
Published inThe Journal of craniofacial surgery Vol. 28; no. 2; p. 489
Main Authors Hirsch, Scott D, Powers, Jeremy M, Rhodes, Jennifer L
Format Journal Article
LanguageEnglish
Published United States 01.03.2017
Subjects
Collagen
Dermatologic Surgical Procedures - methods
Female
Humans
Infant, Newborn
Parenteral Nutrition, Total - adverse effects
Skin, Artificial
Soft Tissue Injuries - etiology
Soft Tissue Injuries - surgery
Wound Healing
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Summary:Total parenteral nutrition (TPN) can be a lifesaving intervention for premature neonates and it is often delivered through peripheral access in this unique population. However, extravasation and tissue damage can result. Current literature lacks strong evidence regarding the treatment and reconstruction of such injuries in this age group. The authors present a patient with a 30-week gestational age premature newborn whom suffered an extravasation injury with peripherally administered TPN leading to full thickness skin and soft tissue necrosis of the dorsum of the right hand. This was serially debrided and ultimately repaired using Apligraf (Graftskin, Living Skin Equivalent, LSE; Organogenesis Inc, Canton, MA), which rapidly facilitated secondary healing.
ISSN:1536-3732
DOI:10.1097/SCS.0000000000003346