A simple synthesis of chiral macrocyclic tetraamides derived from α-amino acids

Bisamidation of oxalyl chloride using four l-α-amino acid esters afforded chiral diesters which were reacted with three α,ω-diamines under high-pressure conditions (10 kbar) to give macrocyclic tetramides of C 2-symmetry. Graphic

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Bibliographic Details
Published inTetrahedron: asymmetry Vol. 13; no. 18; pp. 2053 - 2059
Main Authors Zieliński, Tomasz, Achmatowicz, Michał, Jurczak, Janusz
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 20.09.2002
Elsevier
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Chemistry, Physical
Physical Sciences
Science & Technology
CROWN ETHERS
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Summary:Bisamidation of oxalyl chloride using four l-α-amino acid esters afforded chiral diesters which were reacted with three α,ω-diamines under high-pressure conditions (10 kbar) to give macrocyclic tetramides of C 2-symmetry. Graphic
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(02)00506-2