Polymerization-induced self-assembly for the fabrication of polymeric nano-objects with enhanced structural stability by cross-linking

Polymerization-induced self-assembly (PISA) has been established as a robust strategy to synthesize block copolymer nano-objects with various morphologies, sizes, and surface chemistry, which greatly enlarges the library of functional nano-objects for further applications. The structural stability o...

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Published inPolymer chemistry Vol. 11; no. 22; pp. 3654 - 3672
Main Authors Zhang, Wen-Jian, Kadirkhanov, Jamshid, Wang, Chang-Hui, Ding, Sheng-Gang, Hong, Chun-Yan, Wang, Fei, You, Ye-Zi
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 14.06.2020
Subjects
Block copolymers
Crosslinking
Drug delivery systems
Emulsifiers
Emulsion polymerization
Morphology
Polymer chemistry
Polymerization
Self-assembly
Structural stability
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Summary:Polymerization-induced self-assembly (PISA) has been established as a robust strategy to synthesize block copolymer nano-objects with various morphologies, sizes, and surface chemistry, which greatly enlarges the library of functional nano-objects for further applications. The structural stability of nano-objects is an important concern when they are used in drug delivery, nanoreactors, Pickering emulsifiers, etc . Generally, chemical cross-linking via either post-polymerization or in situ cross-linking strategies has been demonstrated to be a viable strategy to improve the structural stability of the nano-objects. In this review, we focus on the PISA-generated nano-objects with enhanced structural stability via either post-polymerization or in situ cross-linking strategies and their applications. This review discusses the strategies of core-cross-linking in most of the PISA literatures (including post-polymerization cross-linking, photo-cross-linking and in situ cross-linking) and the applications of the cross-linked nano-objects.
Bibliography:Chun-Yan Hong is a professor of the University of Science and Technology of China (USTC). She obtained her PhD in chemistry from the USTC in 2002. Her research interests include controlled radical polymerization, synthesis of stimuli-responsive polymers and biodegradable polymers, fabrication of functionalized nanomaterials and their applications in drug/gene delivery.
Wen-Jian Zhang is an associate professor of the University of Science and Technology of China (USTC). He obtained his PhD in chemistry from the USTC in 2014 under the supervision of Professors Chun-Yan Hong and Cai-Yuan Pan. His research interests include the polymerization-induced self-assembly, functional polymeric nano-objects and their application in drug delivery.
Ye-Zi You is currently a professor of polymer chemistry at the University of Science and Technology of China. He received his B.Sc. (1996) and Ph.D. (2003) from Hefei University of Technology and the University of Science and Technology of China, respectively. He then worked as a visiting scholar and postdoctoral fellow at the Tokyo Institute of Technology and Wayne State University, respectively. He joined the University of Science and Technology of China in 2008. His scientific interest is focused on the controlled release of polymer nanomedicines and tumor treatment.
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ISSN:1759-9954
1759-9962
DOI:10.1039/d0py00368a