Synthesis of Coumarins and Neoflavones through Zinc Chloride Catalyzed Hydroarylation of Acetylenic Esters with Phenols

Acetylenic esters react with oxygenated phenols under solvent-free conditions in the presence of only 5 mol% of zinc chloride as a catalyst to give coumarins and neoflavones in reasonable-to-good yields.

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 22; pp. 3692 - 3696
Main Authors Leao, Raquel A. C., de Moraes, Paula de F., Pedro, Marcella C. B. C., Costa, Paulo R. R.
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.11.2011
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CONVENIENT SYNTHESIS
phenols
MIXTURE
esters
alkynes
catalysis
IODOPHENOLS
HECK-LACTONIZATION
MILD
PECHMANN CONDENSATION
arylations
heterocycles
WARFARIN
CHEMISTRY
INHIBITORS
DERIVATIVES
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Summary:Acetylenic esters react with oxygenated phenols under solvent-free conditions in the presence of only 5 mol% of zinc chloride as a catalyst to give coumarins and neoflavones in reasonable-to-good yields.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0031-1289576