Synthesis and biological activity of a potent antiplatelet 7-aminofurochromone

The synthesis of a series of rigid analogs designed to explore the conformational requirements associated with the related 2-aminochromone 1 led to the identification of class of novel antiplatelet 7-aminofurochromes 2. A potent derivative 13 was further evaluated with regard to mechanism of action...

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Published inBioorganic & medicinal chemistry letters Vol. 4; no. 21; pp. 2621 - 2626
Main Authors Morris, Joel, Wishka, Donn G., Humphrey, William R., Lin, Alice H., Wiltse, Ann L., Benjamin, Christopher W., Gorman, Robert R., Shebuski, Ronald J.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 10.11.1994
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Summary:The synthesis of a series of rigid analogs designed to explore the conformational requirements associated with the related 2-aminochromone 1 led to the identification of class of novel antiplatelet 7-aminofurochromes 2. A potent derivative 13 was further evaluated with regard to mechanism of action as well as in a canine model of platelet dependent thrombus formation. The synthesis of a series of rigid analogs designed to explore the conformational requirements associated with the related antiplatelet 2-aminochromone 1 had led to the identification of a class of novel antiplatelet 7-aminofurochromones (eg. 13).
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80296-1