A useful acylation method using trichloroacetonitrile and triphenylphosphine for solid phase organic synthesis

A novel acylation procedure was developed for polymer supported synthesis, with in situ generated acyl chlorides using trichloroacetonitrile and triphenylphosphine. A new solid phase acylation method with in situ generated acyl chloride is described.

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Bibliographic Details
Published inTetrahedron letters Vol. 43; no. 34; pp. 6039 - 6041
Main Authors Vágó, István, Greiner, István
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 19.08.2002
Elsevier
Subjects
acyl chloride
acylation
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
solid phase synthesis
acyl chloride
acylation
solid phase synthesis
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Summary:A novel acylation procedure was developed for polymer supported synthesis, with in situ generated acyl chlorides using trichloroacetonitrile and triphenylphosphine. A new solid phase acylation method with in situ generated acyl chloride is described.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(02)01241-8