Efficient One-Pot Synthesis of 2-Substituted Benzimidazoles from Triacyloxyborane Intermediates

An efficient one-pot synthesis of 2-substituted benzimidazoles via triacyloxyborane intermediates is reported. The mild protocol is efficient and tolerant of acid-labile functional groups.

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Bibliographic Details
Published inSynlett no. 2; pp. 247 - 250
Main Authors Cui, Wenge, Kargbo, Robert B., Sajjadi-Hashemi, Zohreh, Ahmed, Feryan, Gauuan, Jolicia F.
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.01.2012
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
DESIGN
CASCADE REACTIONS
ACID
MECHANISM
COPPER-CATALYZED SYNTHESIS
carboxylic acids
CONDENSATION
benzoxazoles
benzimidazoles
INHIBITORS
diacyloxyboric acids
borane-THF
MINOR-GROOVE-BINDING
DERIVATIVES
triacyloxyboranes
AMIDES
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Summary:An efficient one-pot synthesis of 2-substituted benzimidazoles via triacyloxyborane intermediates is reported. The mild protocol is efficient and tolerant of acid-labile functional groups.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0031-1290129