Novel Body Composition Predictors of Outcome in Patients With Angiosarcoma of the Breast: A Preliminary Study

• Published in: Journal of computer assisted tomography Vol. 44; no. 4; p. 605
• Main Authors: Hemke, Robert, Takayesu, Jamie, Hughes, Kevin S, Chang, Connie, DeLaney, Thomas F, Bernstein, Karen De Amorim, Bredella, Miriam A
• Format: Journal Article
• Language: English
• Published: United States 01.07.2020
• Subjects: Abdominal Fat - diagnostic imaging; Aged; Aged, 80 and over; Body Composition; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - mortality; Case-Control Studies; Female; Fluorodeoxyglucose F18 - administration & dosage; Hemangiosarcoma - diagnostic imaging; Hemangiosarcoma - mortality; Humans; Middle Aged; Positron Emission Tomography Computed Tomography - methods; Prognosis; Retrospective Studies
• ISSN: 1532-3145
• DOI: 10.1097/RCT.0000000000001066

The aim of the study was to determine abdominal and breast adipose tissue parameters on 18-fluorodeoxyglucose positron emission tomography/computed tomography (CT) that may serve as outcome predictors in breast angiosarcoma patients. Women with breast angiosarcoma (n = 13) who underwent 18-fluorodeoxyglucose positron emission tomography/CT were identified. A control group was selected (n = 25). Abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) were assessed on unenhanced computed tomographies. Breast adipose tissue (BAT) volumes of the uninvolved breast were quantified. Metabolic activity of VAT, SAT, and BAT was calculated (standardized uptake value [SUV]). Breast angiosarcoma patients had higher metabolic activity of VAT compared with controls (SUV 0.93 ± 0.39 vs 0.64 ± 0.11, P = 0.044). Within the patient group, there were 6 deaths (46.2%). Patients who died had higher SAT activity (SUV 0.52 ± 0.24 vs 0.29 ± 0.06, P = 0.027) and higher BAT metabolic activity (SUV 0.48 ± 0.20 vs 0.27 ± 0.11, P = 0.045) compared with nondeceased patients. Patients with breast angiosarcoma have higher metabolic activity of VAT. Higher abdominal SAT and higher BAT metabolic activity of the uninvolved breast might predict mortality.