A formal synthesis of (+)-brefeldin A

A formal synthesis of (+)-brefeldin A has been achieved via stereoselective construction of hydroxycyclopentane skeleton possessing the requisite hydroxyheptenyl side chain. The highly advanced intermediate 2 has been synthesized from the known Weinreb amide in 19% overall yield of 11 steps. A forma...

Full description

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 39; no. 30; pp. 5377 - 5380
Main Authors Suh, Young-Ger, Jung, Jae-Kyung, Suh, Byung-Chul, Lee, Young-Choon, Kim, Soon-Ai
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 23.07.1998
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ENANTIOSELECTIVE SYNTHESIS
STREPTOGRAMIN ANTIBIOTICS
Online AccessGet full text

Cover

More Information
Summary:A formal synthesis of (+)-brefeldin A has been achieved via stereoselective construction of hydroxycyclopentane skeleton possessing the requisite hydroxyheptenyl side chain. The highly advanced intermediate 2 has been synthesized from the known Weinreb amide in 19% overall yield of 11 steps. A formal synthesis of (+)-Brefeldin A has been achieved in 11 steps from Weinreb amide via stereoselective construction of hydroxycyclopentane skeleton possessing the requisite hydroxyheptenyl side chain.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)01078-8