(±)- Trans-2-[3-methoxy-4-(4-chlorophenyl thioethoxy)-5-cyanophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent PAF-receptor antagonist

The synthesis of (±)- trans-2-[3-methoxy-4-(chlorophenylthioethoxyphenyl)-5-cyanophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran from commercially available acetovanillone and 3,4,5-trimethoxybenzaldehyde is described. Graphic

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Bibliographic Details
Published inTetrahedron Vol. 55; no. 33; pp. 10163 - 10172
Main Authors Ram, B, Balram, B, Sai Prakash, P.K
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 13.08.1999
Elsevier
Subjects
5-transdiaryltetrahydrofuran
Acetovanillone
Chemistry
Chemistry, Organic
Physical Sciences
Platelet-activating factor
Science & Technology
2
5-transdiaryltetrahydrofuran
Platelet-activating factor
Acetovanillone
L-659,989
2,5-transdiaryltetrahydrofuran
MK-287
acetovanillone
platelet-activating factor
PLATELET-ACTIVATING-FACTOR
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Summary:The synthesis of (±)- trans-2-[3-methoxy-4-(chlorophenylthioethoxyphenyl)-5-cyanophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran from commercially available acetovanillone and 3,4,5-trimethoxybenzaldehyde is described. Graphic
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(99)00544-X