Microwave activated solvent-free cascade reactions yielding highly functionalised 1,3-thiazines

One-pot cascade reactions of N-acylglycines, acetic anhydride, anhydrous sodium acetate, aromatic aldehydes, and ammonium N-aryldithiocarbamates expeditiously and diastereoselectively yield 5-acylamino-3,6-diarylperhydro-2-thioxo-1,3-thiazin-4-ones ( 5a– j ) in solvent-free conditions under microwav...

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Bibliographic Details
Published inTetrahedron letters Vol. 44; no. 30; pp. 5637 - 5640
Main Authors Yadav, Lal Dhar S., Singh, Amrish
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 21.07.2003
Elsevier
Subjects
1,3-thiazines
Chemistry
Chemistry, Organic
dithiocarbamates
microwaves
Physical Sciences
Science & Technology
solvent-free cascade reactions
stereoselective synthesis
microwaves
dithiocarbamates
solvent-free cascade reactions
1,3-thiazines
stereoselective synthesis
ORGANIC-SYNTHESIS
ALDOL CONDENSATIONS
DERIVATIVES
CYCLIZATION
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Summary:One-pot cascade reactions of N-acylglycines, acetic anhydride, anhydrous sodium acetate, aromatic aldehydes, and ammonium N-aryldithiocarbamates expeditiously and diastereoselectively yield 5-acylamino-3,6-diarylperhydro-2-thioxo-1,3-thiazin-4-ones ( 5a– j ) in solvent-free conditions under microwave irradiation. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(03)01353-4