Extracellular fluid miRNAs in PCOS

• Published in: Clinica chimica acta Vol. 576; p. 120404
• Main Authors: Hadi, Saba, Khoshraftar, Seyed Hossein, Kiani Darabi, Amir Hossein, Soleimani, Anahita, Nejabati, Hamid Reza
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.08.2025
• Subjects: Biomarkers - metabolism; Endocrine; Extracellular Fluid - metabolism; Female; Humans; Metabolic; MicroRNAs - genetics; MicroRNAs - metabolism; miRNAs; PCOS; Polycystic Ovary Syndrome - diagnosis; Polycystic Ovary Syndrome - genetics; Polycystic Ovary Syndrome - metabolism; Endocrine; PCOS; Metabolic; miRNAs
• ISSN: 0009-8981; 1873-3492; 1873-3492
• DOI: 10.1016/j.cca.2025.120404

•PCOS is a prevalent condition that impacts both reproductive functioning.•miRNAs are small non-coding RNAs that regulate gene expression.•miRNA expression profiles are notably different between PCOS and healthy subjects. Polycystic ovary syndrome (PCOS) is a prevalent endocrine condition that impacts both reproductive and metabolic functioning. Despite thorough research, the exact causes of PCOS remain unclear. Recent studies indicate that microRNAs (miRNAs), which are small non-coding RNAs that regulate gene expression, could be crucial for comprehending PCOS. This review article investigates the variations in extracellular fluids miRNAs expression in individuals diagnosed with PCOS and assesses their viability as diagnostic biomarkers, and determines their involvement in the mechanisms underlying the disease. The related reports show that miRNA expression profiles demonstrate notable differences between PCOS patients and healthy subjects. Several miRNAs exhibit dysregulation in essential biological processes such as follicular development, steroidogenesis, insulin signaling, and metabolic pathways. These results imply that miRNAs could lead to hormonal imbalances and metabolic problems linked to PCOS. The variations in miRNA expression noted in patients with PCOS underscore their possible role as biomarkers for the early detection and characterization of the condition. Continued investigation into miRNA-based diagnostic and therapeutic strategies may enhance our comprehension of PCOS. and facilitate the advancement of more precise therapeutic alternatives.