An easy palladium-catalyzed access to 2-alkylidene-1,4-benzodioxanes

Palladium-catalyzed cyclization of benzene-1,2-diol with various propargylic carbonates led to 2-alkylidene-1,4-benzodioxanes in excellent chemical yields. Diphosphines such as dppb, dpppe or dpph, and monophosphines are the best ligands. Graphic

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Bibliographic Details
Published inTetrahedron letters Vol. 40; no. 51; pp. 9025 - 9028
Main Authors Labrosse, Jean-Robert, Lhoste, Paul, Sinou, Denis
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 17.12.1999
Elsevier
Subjects
2-alkylidene-1,4-benzodioxanes
benzene-1,2-diol
Chemistry
Chemistry, Organic
cyclization reaction
palladium
Physical Sciences
propargylic carbonate
Science & Technology
cyclization reaction
benzene-1,2-diol
palladium
2-alkylidene-1,4-benzodioxanes
propargylic carbonate
CONVENIENT SYNTHESIS
ABSOLUTE-CONFIGURATION
1,4-BENZODIOXIN
ANALOGS
ANTAGONISTS
DERIVATIVES
STEREOSELECTIVE SYNTHESIS
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Summary:Palladium-catalyzed cyclization of benzene-1,2-diol with various propargylic carbonates led to 2-alkylidene-1,4-benzodioxanes in excellent chemical yields. Diphosphines such as dppb, dpppe or dpph, and monophosphines are the best ligands. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(99)01919-X