The synthesis of substituted pyridylpyrimidine fungicides using palladium-catalysed cross-coupling reactions

• Published in: Tetrahedron letters Vol. 41; no. 10; pp. 1653 - 1656
• Main Authors: Hargreaves, Stephanie L, Pilkington, Brian L, Russell, Sally E, Worthington, Paul A
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 04.03.2000; Elsevier
• Subjects: Chemistry; Chemistry, Organic; coupling reactions; fungicides; palladium catalysts; Physical Sciences; pyridines, pyrimidines; Science & Technology; pyridines, pyrimidines; palladium catalysts; fungicides; coupling reactions; pyridines; pyrimidines

Various substituted phenyl, pyridyl and benzyl zinc chlorides have been generated from the corresponding lithium or magnesium organometallic reagents. These have been cross-coupled with 2-(6-bromo-2-pyridyl)pyrimidines in the presence of tetra kis(triphenylphosphine)palladium(0) to produce a series...