The synthesis of substituted pyridylpyrimidine fungicides using palladium-catalysed cross-coupling reactions

Various substituted phenyl, pyridyl and benzyl zinc chlorides have been generated from the corresponding lithium or magnesium organometallic reagents. These have been cross-coupled with 2-(6-bromo-2-pyridyl)pyrimidines in the presence of tetra kis(triphenylphosphine)palladium(0) to produce a series...

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Bibliographic Details
Published inTetrahedron letters Vol. 41; no. 10; pp. 1653 - 1656
Main Authors Hargreaves, Stephanie L, Pilkington, Brian L, Russell, Sally E, Worthington, Paul A
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 04.03.2000
Elsevier
Subjects
Chemistry
Chemistry, Organic
coupling reactions
fungicides
palladium catalysts
Physical Sciences
pyridines, pyrimidines
Science & Technology
pyridines, pyrimidines
palladium catalysts
fungicides
coupling reactions
pyridines
pyrimidines
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Summary:Various substituted phenyl, pyridyl and benzyl zinc chlorides have been generated from the corresponding lithium or magnesium organometallic reagents. These have been cross-coupled with 2-(6-bromo-2-pyridyl)pyrimidines in the presence of tetra kis(triphenylphosphine)palladium(0) to produce a series of substituted pyridylpyrimidine fungicides in 32–99% yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)00007-1