Kinetic Stability and Glass-Forming Ability of Phenacetin According to Fast Scanning Calorimetry

The active amorphous pharmaceutical ingredient, phenacetin, was obtained by the fast scanning calorimetry method. The critical cooling rate and kinetic fragility of its supercooled melt were determined. The process of phenacetin cold crystallization was studied by the methods of isothermal and non-i...

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 93; no. 5; pp. 1138 - 1143
Main Authors Lapuk, S. E., Gerasimov, A. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.05.2023
Springer
Springer Nature B.V
Subjects
Acetanilide
Calorimetry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cold crystallization
Cooling rate
Fragility
Heat measurement
Scanning
active pharmaceutical ingredient
glass-forming ability
fast scanning calorimetry
crystallization kinetics
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Summary:The active amorphous pharmaceutical ingredient, phenacetin, was obtained by the fast scanning calorimetry method. The critical cooling rate and kinetic fragility of its supercooled melt were determined. The process of phenacetin cold crystallization was studied by the methods of isothermal and non-isothermal kinetics. The best correspondence between the two kinetic approaches is observed in the case of the Nakamura crystallization model. The results obtained can be used in the development of approaches to obtaining amorphous forms of drugs prone to crystallization.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363223050146