Design and synthesis of multifunctional phospholipids

The synthesis of a bifunctionalized phosholipid capable of binding streptavidin or poly-histidine-tagged proteins is reported for the first time. The head group containing both a biotin and an NTA chelator is synthesized via a new approach using solid phase synthesis.

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Bibliographic Details
Published inTetrahedron letters Vol. 41; no. 21; pp. 4131 - 4134
Main Authors Drakopoulou, Eugenia, Tsivgoulis, Gerasimos M., Mukhopadhyay, Anneke, Brisson, Alain
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 29.05.2000
Elsevier
Subjects
biotin
Chemistry
Chemistry, Organic
molecular recognition
nickel-chelators
phospholipids
Physical Sciences
Science & Technology
solid phase synthesis
nickel-chelators
molecular recognition
solid phase synthesis
phospholipids
biotin
PEPTIDES
HELICAL CRYSTALLIZATION
PROTEINS
LIPIDS
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Summary:The synthesis of a bifunctionalized phosholipid capable of binding streptavidin or poly-histidine-tagged proteins is reported for the first time. The head group containing both a biotin and an NTA chelator is synthesized via a new approach using solid phase synthesis.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)00596-7