Impact of long-term antiretroviral therapy interruption and resumption on viral reservoir in HIV-1 infected patients

: We assessed if the increase on viral reservoir after long-term antiretroviral therapy (ART) interruption (ATI) is reversible upon ART resumption in chronic HIV-1 infected patients. Total HIV-1 DNA increased to pre-ART levels after 48 weeks of ATI to return to pre-ATI levels after 104 weeks of ART...

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Bibliographic Details
Published inAIDS (London) Vol. 31; no. 13; pp. 1895 - 1897
Main Authors Montserrat, Marta, Plana, Montserrat, Guardo, Alberto C, Andrés, Cristina, Climent, Nuria, Gallart, Teresa, Leal, Lorna, Gatell, Josep M, Sánchez-Palomino, Sonsoles, García, Felipe
Format Journal Article
LanguageEnglish
Published England 24.08.2017
Subjects
AIDS/HIV
Anti-Retroviral Agents - administration & dosage
Antiretroviral Therapy, Highly Active - methods
DNA, Viral - analysis
HIV Infections - drug therapy
HIV Infections - virology
HIV-1 - genetics
HIV-1 - isolation & purification
HIV-1 - physiology
Humans
Viral Load
Virus Integration
Withholding Treatment
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Summary:: We assessed if the increase on viral reservoir after long-term antiretroviral therapy (ART) interruption (ATI) is reversible upon ART resumption in chronic HIV-1 infected patients. Total HIV-1 DNA increased to pre-ART levels after 48 weeks of ATI to return to pre-ATI levels after 104 weeks of ART resumption. Conversely, integrated HIV-1 DNA remained elevated after ART reinitiation. These data suggest that the increase in reservoir after long-term ART discontinuation might not be reversible at midterm.
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ISSN:0269-9370
1473-5571
DOI:10.1097/QAD.0000000000001560