Morning blood pressure surge is associated with carotid intima-media thickness in prehypertensive patients

• Published in: Blood pressure monitoring Vol. 22; no. 3; p. 131
• Main Authors: Alpaydin, Sertac, Turan, Yasar, Caliskan, Mustafa, Caliskan, Zuhal, Aksu, Feyza, Ozyildirim, Serhan, Buyukterzi, Zafer, Kostek, Osman, Muderrisoglu, Haldun
• Format: Journal Article
• Language: English
• Published: England 01.06.2017
• Subjects: Adult; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Carotid Arteries - diagnostic imaging; Carotid Intima-Media Thickness; Female; Humans; Hypertension - diagnosis; Hypertension - diagnostic imaging; Hypertension - physiopathology; Male; Mean Platelet Volume; Middle Aged
• ISSN: 1473-5725
• DOI: 10.1097/MBP.0000000000000252

Morning blood pressure (BP) surge (MBPS) is defined as an excessive increase in the morning BP from the lowest systolic BP during sleep and is reported as a risk factor for cardiovascular events in current clinical studies. In this study, we aimed to investigate the relationship between MBPS and carotid intima-media thickness (C-IMT) in prehypertensive patients. We evaluated the association between the rate of BP variation derived from ambulatory BP monitoring and C-IMT in patients with prehypertension. One hundred and seventy patients with prehypertension were included in the study. All office BP measurements and ambulatory 24-h, day-time, and night-time measurements were similar between each group. C-IMT [0.60 (range: 0.57-0.65) vs. 0.55 (range: 0.50-0.60) cm; P<0.001] and the mean platelet volume [8.7 (range: 7.9-9.1) vs. 7.9 (range: 7.3-8.8)  fl; P=0.002] were significantly higher in the greater MBPS group than the lower group. In multivariate analysis, male sex [odds ratio (OR): 2.271, confidence interval (CI): 1.011-5.100, P=0.047], greater MBPS (OR: 8.474, CI: 3.623-19.608, P<0.001), and elevated mean platelet volume levels (OR: 3.359, CI: 1.978-5.705, P<0.001) were found to be independent predictors of greater C-IMT in prehypertensive patients. Our study suggests that greater MBPS is associated independently with C-IMT in prehypertensive patients.