A new approach to polyfluoroaromatic amines with an unsubstituted position ortho to the amino group

N-acetyl derivatives of polyfluoroaromatic amines have been found to be highly selectively defluorinated by zinc in aqueous ammonia at the position ortho to the acetamido group thus affording a new approach to potential building blocks for the synthesis of polyfluorobenzheterocycles.

Saved in:
Bibliographic Details
Published inJournal of fluorine chemistry Vol. 110; no. 1; pp. 43 - 46
Main Authors Laev, Sergey S, Evtefeev, Vladimir U, Shteingarts, Vitalij D
Format Journal Article
LanguageEnglish
Published LAUSANNE Elsevier B.V 2001
Elsevier
Subjects
Acetamido group
Aqueous ammonia
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Hydrodefluorination
N-acetyl derivatives
Physical Sciences
Polyfluoroaromatic amines
Reductive defluorination
Science & Technology
Zinc
Hydrodefluorination
Aqueous ammonia
Acetamido group
Polyfluoroaromatic amines
Reductive defluorination
Zinc
N-acetyl derivatives
polyfluoroaromatic amines
reductive defluorination
hydrodefluorination
aqueous ammonia
acetamido group
zinc
Online AccessGet full text

Cover

More Information
Summary:N-acetyl derivatives of polyfluoroaromatic amines have been found to be highly selectively defluorinated by zinc in aqueous ammonia at the position ortho to the acetamido group thus affording a new approach to potential building blocks for the synthesis of polyfluorobenzheterocycles.
ISSN:0022-1139
1873-3328
DOI:10.1016/S0022-1139(01)00404-3