Synthesis and mechanistic studies of a ‘tetrazole-tethered” cephalosporin-quinolone hybrid
The synthesis and antibacterial activity of a novel ‘tetrazole-tethered’ cephalosporin-quinolone hybrid is described. The in vitro spectrum of 7 mirrored that of a third-generation cephalosporin. Quinolone-like activity was not observed. β-Lactamase-accelerated hydrolysis of 7 produced tetrazolylqui...
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| Published in | Bioorganic & medicinal chemistry letters Vol. 3; no. 2; pp. 209 - 214 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Ltd
01.02.1993
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| Online Access | Get full text |
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| Summary: | The synthesis and antibacterial activity of a novel ‘tetrazole-tethered’ cephalosporin-quinolone hybrid is described. The
in vitro spectrum of
7 mirrored that of a third-generation cephalosporin. Quinolone-like activity was not observed. β-Lactamase-accelerated hydrolysis of
7 produced tetrazolylquinolone
12 which (
via independent synthesis) proved to be a weak antibacterial and unable to form free quinolone.
The synthesis, antibacterial activity and mechanistic studies of a ‘tetrazole-tethered’ cephalosporin-quinolone hybrid is described. The in vitro spectrum of
7 mirrored that of a third-generation cephalosporin. Quinolone-like activity was not observed. β-Lactamase-accelerated hydrolysis of
7 produced tetrazolylquinolone
12 which proved to be a weak antibacterial and unable to form free quinolone. |
|---|---|
| ISSN: | 0960-894X 1464-3405 |
| DOI: | 10.1016/S0960-894X(01)80878-7 |