Synthesis of New Dihydropyrimido[4,5-b]quinolinetrione Derivatives Using a Four-Component Coupling Reaction

A convenient and one-pot method for the efficient synthesis of the novel 8,9-dihydro-8,8-dimethyl-5,10-diphenylpyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)-trione derivatives via a four-component condensation reaction of aldehydes, amines, dimedone, and barbituric acid in the presence of tungesto...

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 6; pp. 984 - 992
Main Authors Khalafi-Nezhad, A., Panahi, F.
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.03.2011
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
DIVERSITY-ORIENTED SYNTHESIS
multicomponent reaction
pyrimidine
dihydropyridine
dimedone
barbituric acid
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Summary:A convenient and one-pot method for the efficient synthesis of the novel 8,9-dihydro-8,8-dimethyl-5,10-diphenylpyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)-trione derivatives via a four-component condensation reaction of aldehydes, amines, dimedone, and barbituric acid in the presence of tungestophosphoric acid (H3PW12O40) as catalyst is described. This new approach proceeded smoothly in good to excellent yields and the pure products are separated from the reaction mixture by simple filtration.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0030-1258446