On the biosynthesis of an inhibitor of the p53/MDM2 interaction

The biosynthesis of a fungal secondary metabolite, chlorofusin, which disrupts the interaction between the proteins p53 and MDM2, has been investigated; the acetogenic origin of the chromophore backbone as well as of an aminodecanoic acid residue is demonstrated. Graphic

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Bibliographic Details
Published inTetrahedron letters Vol. 43; no. 6; pp. 1075 - 1078
Main Authors Duncan, Sara J, Williams, Dudley H, Ainsworth, Martyn, Martin, Steven, Ford, Robert, Wrigley, Stephen K
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 04.02.2002
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
MONASCUS
MDM2
ALKALOIDS
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Summary:The biosynthesis of a fungal secondary metabolite, chlorofusin, which disrupts the interaction between the proteins p53 and MDM2, has been investigated; the acetogenic origin of the chromophore backbone as well as of an aminodecanoic acid residue is demonstrated. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)02239-0