The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor

An efficient synthetic strategy has been developed for the synthesis of a novel fructose conjugated S-nitroso nitric oxide donor, fructose-1- S-nitroso- N-acetylpenicillamine. This compound showed similar cytotoxicity as the first generation fructose-SNAP, fructose-2-SNAP. A 5- and 26-fold increased...

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Published inTetrahedron letters Vol. 42; no. 5; pp. 825 - 829
Main Authors Hou, Yongchun, Wu, Xuejun, Xie, Wenhua, Braunschweiger, Paul G, Wang, Peng G
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 29.01.2001
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:An efficient synthetic strategy has been developed for the synthesis of a novel fructose conjugated S-nitroso nitric oxide donor, fructose-1- S-nitroso- N-acetylpenicillamine. This compound showed similar cytotoxicity as the first generation fructose-SNAP, fructose-2-SNAP. A 5- and 26-fold increased cytotoxicity was observed compared to glucose-2-SNAP and SNAP against DU-145 human prostate cancer cells in vitro. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)02158-4