The first titanocenyl dichloride moiety vectorised by a selective estrogen receptor modulator (SERM). Synthesis and preliminary biochemical behaviour

The synthesis of 4′, a titanocene derivative of the anticancer drug tamoxifen is presented together with its biochemical properties. Compound 4′ is prepared by a McMurry coupling followed by a ligand exchange. Compound 4′ reveals an unexpected proliferative effect on the hormone-dependent cell line...

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Bibliographic Details
Published inJournal of organometallic chemistry Vol. 643; pp. 350 - 356
Main Authors Top, S, Kaloun, E.B, Vessières, A, Laı̈os, I, Leclercq, G, Jaouen, G
Format Journal Article
LanguageEnglish
Published LAUSANNE Elsevier B.V 01.02.2002
Elsevier
Subjects
Bioorganometallic
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Estrogen
MCF7
Physical Sciences
Proliferative effect
Science & Technology
SERM
Tamoxifen
Titanocen
Proliferative effect
Titanocen
MCF7
Bioorganometallic
Estrogen
SERM
Tamoxifen
ANTITUMOR AGENTS
titanocen
estrogen
proliferative effect
COMPLEXES
PLATINUM
ALPHA
bioorganometallic
CANCER
tamoxifen
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Summary:The synthesis of 4′, a titanocene derivative of the anticancer drug tamoxifen is presented together with its biochemical properties. Compound 4′ is prepared by a McMurry coupling followed by a ligand exchange. Compound 4′ reveals an unexpected proliferative effect on the hormone-dependent cell line MCF7. Surprisingly this effect is also observed with Cp 2TiCl 2 alone. The synthesis of 4′, a titanocene derivative of the anticancer drug tamoxifen is presented together with its biochemical properties. Compound 4′ is prepared by a McMurry coupling followed by a ligand exchange. Compound 4′ reveals an unexpected proliferative effect on the hormone-dependent cell line MCF7. Surprisingly this effect is also observed with Cp 2TiCl 2 alone.
ISSN:0022-328X
1872-8561
DOI:10.1016/S0022-328X(01)01271-2