Composite Matrices Based on Copolyamide and Polypyrrole for Tissue Engineering

We have demonstrated the possibility of application of electroconducting polymers for fabricating bioactive matrices for tissue engineering. Polypyrrole is most promising among such polymers in the context of its biomedical applications. Polypyrrole possesses a number of properties that make it an a...

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Published inTechnical physics Vol. 65; no. 10; pp. 1574 - 1579
Main Authors Smirnova, N. V., Sapurina, I. Yu, Shishov, M. A., Kolbe, K. A., Ivan’kova, E. M., Matrenichev, V. V., Yudin, V. E.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.10.2020
Springer
Springer Nature B.V
Subjects
Biocompatibility
Biological activity
Biomedical materials
Classical and Continuum Physics
Dielectric films
Electric properties
Electrical conductivity
Electrical resistivity
Electroforming
Fibroblasts
Mechanical properties
Oxidation
Physics
Physics and Astronomy
Polymer Materials for Biomedicine
Polymerization
Polymers
Polypyrroles
Thin films
Tissue engineering
Trade show management firms
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Summary:We have demonstrated the possibility of application of electroconducting polymers for fabricating bioactive matrices for tissue engineering. Polypyrrole is most promising among such polymers in the context of its biomedical applications. Polypyrrole possesses a number of properties that make it an adequate basis for preparing “smart” bioactive materials. To obtain the best mechanical properties of composite matrices, we used aliphatic copolyamide. The matrices obtained from the copolyamide solution had the structure of thin films, as well as fibrous nonwoven mats prepared by electroformation. Copolyamide films were modified with polypyrrole using polymerization by oxidation with the formation of composite matrices. The samples obtained in this way exhibited service properties acceptable for applications and an electric conductivity level sufficient for cell technologies. In the in vitro experiments, the copolyamide- and polypyrrole-based matrices support the viability, adhesion, and proliferation of human dermal fibroblasts.
ISSN:1063-7842
1090-6525
DOI:10.1134/S1063784220100217