OPTICAL COHERENCE TOMOGRAPHY AND OCT ANGIOGRAPHY CHARACTERISTICS OF INDOCYANINE GREEN ANGIOGRAPHIC PLAQUES IN NONEXUDATIVE AGE-RELATED MACULAR DEGENERATION

• Published in: Retina (Philadelphia, Pa.) Vol. 43; no. 1; p. 16
• Main Authors: Stattin, Martin, Ahmed, Daniel, Haas, Anna-Maria, Graf, Alexandra, Zehetner, Claus, Mihalics, Stefan, Krepler, Katharina, Ansari-Shahrezaei, Siamak
• Format: Journal Article
• Language: English
• Published: United States 01.01.2023
• Subjects: Atrophy; Choroidal Neovascularization - diagnosis; Cross-Sectional Studies; Fluorescein Angiography - methods; Geographic Atrophy - diagnosis; Humans; Indocyanine Green; Retrospective Studies; Tomography, Optical Coherence - methods
• ISSN: 1539-2864
• DOI: 10.1097/IAE.0000000000003639

To describe characteristics of indocyanine green (ICG) angiographic plaques in the nonexudative fellow eye of White patients with unilateral treatment-naïve exudative neovascular age-related macular degeneration through optical coherence tomography (OCT) and OCT angiography (OCTA). In this retrospective cross-sectional study, nonexudative eyes with ICG angiographic plaques were analyzed by OCT B-scans for the sensitivity of a double-layer sign, a pigment epithelium detachment, outer retinal atrophy, hyperreflective dots, and subretinal hyperreflective material (SRHM). The ICG angiographic plaque was matched with a macular neovascularization in OCTA en face scans and color-coded B scans. In total, 35 ICG angiographic plaques in 33 of 291 (11%) nonexudative eyes were diagnosed. OCT revealed 27 double-layer sign (78%), eight pigment epithelium detachment (23%), 8 outer retinal atrophy (23%), eight hyperreflective dots (23%), and one subretinal hyperreflective material (3%). OCTA confirmed a macular neovascularization in 28 plaques (80%): 7 (20%) in en face scans, 3 (9%) in color-coded B scans, and 18 (51%) in both. The area size in OCTA was significantly smaller than that of ICG angiography ( P = 0.002). The diagnosis of an ICG angiographic plaque in nonexudative fellow eyes of Whites with unilateral treatment-naïve exudative neovascular age-related macular degeneration was highly suggestive of a typical macular neovascularization type 1 as characterized by OCT and OCTA.