Synthesis of tolypocladin and isotolypocladin

Total synthesis of the microbial metabolite tolypocladin ( 1) and isomeric isotolypocladin ( 2) is described using Friedel-Crafts acylation for condensation of the 2-aza-anthraquinone-(9,10) ring. Total synthesis of the microbial titel metabolites under Friedel-Crafts conditions:

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Bibliographic Details
Published inTetrahedron Vol. 53; no. 1; pp. 109 - 118
Main Authors Werner, Walter, Gräfe, Udo, Ihn, Wolfgang, Tresselt, Dieter, Winter, Stefan, Paulus, Erich
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 06.01.1997
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:Total synthesis of the microbial metabolite tolypocladin ( 1) and isomeric isotolypocladin ( 2) is described using Friedel-Crafts acylation for condensation of the 2-aza-anthraquinone-(9,10) ring. Total synthesis of the microbial titel metabolites under Friedel-Crafts conditions:
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(96)00956-8