Selective deprotection of alkyl t-butyldimethylsilyl ethers in the presence of aryl t-butyldimethylsilyl ethers with bismuth bromide

Alkyl t-butyldimethylsilyl ethers can be selectively cleaved in the presence of aryl ethers using a catalytic amount of bismuth bromide in wet acetonitrile at ambient temperatures.

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 41; no. 32; pp. 6021 - 6024
Main Authors Bajwa, Joginder S., Vivelo, James, Slade, Joel, Repič, Oljan, Blacklock, Thomas
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 05.08.2000
Elsevier
Subjects
alkyl ethers
aryl ethers
bismuth bromide
Chemistry
Chemistry, Organic
group transformation
Physical Sciences
Science & Technology
selective hydrolysis
group transformation
alkyl ethers
bismuth bromide
selective hydrolysis
aryl ethers
PHENOLIC SILYL ETHERS
ION
TRIALKYLSILYL ETHERS
CLEAVAGE
EFFICIENT METHOD
BASE
MILD
REMOVAL
PROTECTING GROUPS
DESILYLATION
Online AccessGet full text

Cover

More Information
Summary:Alkyl t-butyldimethylsilyl ethers can be selectively cleaved in the presence of aryl ethers using a catalytic amount of bismuth bromide in wet acetonitrile at ambient temperatures.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)01012-1