Merkel Cell Carcinoma Arising in an Epidermal Cyst

Merkel cell carcinoma is a rare aggressive primary cutaneous neuroendocrine tumor. It is associated mostly with malignant skin lesions. Rare cases in the literature described its association with benign skin adnexal lesions. We present here an additional case of Merkel cell carcinoma arising from an...

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Bibliographic Details
Published inThe American journal of dermatopathology Vol. 39; no. 11; p. 842
Main Authors Aljufairi, Eman, Alhilli, Fayek
Format Journal Article
LanguageEnglish
Published United States 01.11.2017
Subjects
Biomarkers, Tumor - analysis
Biopsy
Carcinoma, Merkel Cell - chemistry
Carcinoma, Merkel Cell - pathology
Carcinoma, Merkel Cell - surgery
Diagnosis, Differential
Epidermal Cyst - pathology
Epidermal Cyst - surgery
Humans
Immunohistochemistry
Male
Middle Aged
Predictive Value of Tests
Radiotherapy, Adjuvant
Skin Neoplasms - chemistry
Skin Neoplasms - pathology
Skin Neoplasms - surgery
Time Factors
Treatment Outcome
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Summary:Merkel cell carcinoma is a rare aggressive primary cutaneous neuroendocrine tumor. It is associated mostly with malignant skin lesions. Rare cases in the literature described its association with benign skin adnexal lesions. We present here an additional case of Merkel cell carcinoma arising from an epidermal cyst located in the left arm of a 57-year-old male. The tumor was composed of lobules of monotonous round cells with dusty chromatin. It was positive for cytokeratin 20 and neuroendocrine markers. Patient was treated with surgical resection and radiation to the axilla. He is well and free of disease after 5 years of follow-up.
ISSN:1533-0311
DOI:10.1097/DAD.0000000000000745