11-Hydroxy-7-Methoxy-2,8-Dimethyltetracene-5,12-Dione

Microorganisms are a valuable source of pharmaceutically active chemicals, serving as scaffolds for synthesis as well as lead structures. Investigating novel biomes frequently yields intriguing chemistry; the Atacama Desert in Chile is one such example. This study reports the isolation of a new redu...

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Published inMolBank Vol. 2024; no. 2; p. M1822
Main Authors Astakala, Rishi Vachaspathy, Preet, Gagan, Haj Hasan, Ahlam, Desai, Ria, Asenjo, Juan A, Andrews, Barbara, Harrison, William T. A, Ebel, Rainer, Jaspars, Marcel
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.06.2024
Subjects
actinobacteria
Analysis
Anthracyclines
Atacama Desert
Carbon
Crystallography
Deserts
Fungi
Identification and classification
Methods
Methyl groups
NMR
Nuclear magnetic resonance
Pathogens
Properties
Saccharothrix
Separation (Technology)
Staphylococcus infections
Structural analysis
Structure
X-ray crystallography
United Kingdom
United Kingdom > UK
Atacama Desert
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Abstract Microorganisms are a valuable source of pharmaceutically active chemicals, serving as scaffolds for synthesis as well as lead structures. Investigating novel biomes frequently yields intriguing chemistry; the Atacama Desert in Chile is one such example. This study reports the isolation of a new reduced anthracycline-related compound from the Atacama Desert-derived bacterium Saccharothrix S26. Structural characterisation was achieved by one-dimensional and two-dimensional NMR, HR-LCMS, and X-ray crystallography. The compound was tested against the ESKAPE pathogens, bovine mastitis-related pathogens, and the fungal strain Cryptococcus neoformans, but no antimicrobial activity was observed.
AbstractList Microorganisms are a valuable source of pharmaceutically active chemicals, serving as scaffolds for synthesis as well as lead structures. Investigating novel biomes frequently yields intriguing chemistry; the Atacama Desert in Chile is one such example. This study reports the isolation of a new reduced anthracycline-related compound from the Atacama Desert-derived bacterium Saccharothrix S26 . Structural characterisation was achieved by one-dimensional and two-dimensional NMR, HR-LCMS, and X-ray crystallography. The compound was tested against the ESKAPE pathogens, bovine mastitis-related pathogens, and the fungal strain Cryptococcus neoformans , but no antimicrobial activity was observed.
Audience Academic
Author Asenjo, Juan A
Desai, Ria
Preet, Gagan
Haj Hasan, Ahlam
Harrison, William T. A
Andrews, Barbara
Astakala, Rishi Vachaspathy
Ebel, Rainer
Jaspars, Marcel
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Cites_doi 10.1038/ja.2011.87
10.1021/np200320u
10.1107/S2056989019016244
10.1007/978-3-540-74231-9_6
10.1038/ja.2016.78
10.1007/s00203-019-01634-y
10.7164/antibiotics.47.976
10.1107/S2053229614024218
10.3390/molecules27217185
10.1107/S2053273314026370
ContentType Journal Article
Copyright COPYRIGHT 2024 MDPI AG
2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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SubjectTerms actinobacteria
Analysis
Anthracyclines
Atacama Desert
Carbon
Crystallography
Deserts
Fungi
Identification and classification
Methods
Methyl groups
NMR
Nuclear magnetic resonance
Pathogens
Properties
Saccharothrix
Separation (Technology)
Staphylococcus infections
Structural analysis
Structure
X-ray crystallography
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Title 11-Hydroxy-7-Methoxy-2,8-Dimethyltetracene-5,12-Dione
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