11-Hydroxy-7-Methoxy-2,8-Dimethyltetracene-5,12-Dione

Microorganisms are a valuable source of pharmaceutically active chemicals, serving as scaffolds for synthesis as well as lead structures. Investigating novel biomes frequently yields intriguing chemistry; the Atacama Desert in Chile is one such example. This study reports the isolation of a new redu...

Full description

Saved in:
Bibliographic Details
Published inMolBank Vol. 2024; no. 2; p. M1822
Main Authors Astakala, Rishi Vachaspathy, Preet, Gagan, Haj Hasan, Ahlam, Desai, Ria, Asenjo, Juan A, Andrews, Barbara, Harrison, William T. A, Ebel, Rainer, Jaspars, Marcel
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.06.2024
Subjects
actinobacteria
Analysis
Anthracyclines
Atacama Desert
Carbon
Crystallography
Deserts
Fungi
Identification and classification
Methods
Methyl groups
NMR
Nuclear magnetic resonance
Pathogens
Properties
Saccharothrix
Separation (Technology)
Staphylococcus infections
Structural analysis
Structure
X-ray crystallography
United Kingdom
United Kingdom > UK
Atacama Desert
Online AccessGet full text

Cover

More Information
Summary:Microorganisms are a valuable source of pharmaceutically active chemicals, serving as scaffolds for synthesis as well as lead structures. Investigating novel biomes frequently yields intriguing chemistry; the Atacama Desert in Chile is one such example. This study reports the isolation of a new reduced anthracycline-related compound from the Atacama Desert-derived bacterium Saccharothrix S26. Structural characterisation was achieved by one-dimensional and two-dimensional NMR, HR-LCMS, and X-ray crystallography. The compound was tested against the ESKAPE pathogens, bovine mastitis-related pathogens, and the fungal strain Cryptococcus neoformans, but no antimicrobial activity was observed.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1822