Ischemia-modified albumin and inflammatory biomarkers in patients with prostate cancer

Prostate cancer has become a public health problem in many countries and there is evidence which indicates that inflammation and oxidative stress play a key role in the pathogenesis of this disease. Thus, the aim of this study was to evaluate the concentrations of new biomarkers of oxidative stress,...

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Published inClinical laboratory (Heidelberg) Vol. 60; no. 10; p. 1703
Main Authors Da Silveira, Rafael Arrua, Hermes, Carine Lima, Almeida, Taís Corrêa, Bochi, Guilherme Vargas, De Bona, Karine Santos, Moretto, Maria Beatriz, Moresco, Rafael Noal
Format Journal Article
LanguageEnglish
Published Germany 2014
Subjects
Aged
Antioxidants - analysis
Biomarkers - blood
Biomarkers, Tumor - blood
Case-Control Studies
Humans
Inflammation Mediators - blood
Male
Middle Aged
Oxidative Stress
Prostatic Neoplasms - blood
Prostatic Neoplasms - immunology
Serum Albumin
Serum Albumin, Human
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Summary:Prostate cancer has become a public health problem in many countries and there is evidence which indicates that inflammation and oxidative stress play a key role in the pathogenesis of this disease. Thus, the aim of this study was to evaluate the concentrations of new biomarkers of oxidative stress, ischemia-modified albumin (IMA) and ferric reducing ability of plasma (FRAP), as well as the inflammatory markers in patients with prostate cancer. CRP, IMA, FRAP, fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, uric acid, creatinine, albumin, AST, ALT, ADA, total PSA (tPSA), free PSA, and proportion of free PSA (fPSA%) were measured in 25 patients with prostate cancer and in 30 healthy subjects. tPSA, CRP, and IMA were significantly higher in patients with prostate cancer. In contrast, fPSA% and FRAP were significantly lower in these patients. However, no significant differences were observed when IMA values were adjusted for serum albumin. Significant correlations were also observed for tPSA and CRP (r = 0.5104, p < 0.001) and for fPSA% and CRP (r = -0.5059, p < 0.001). We demonstrated that both inflammatory and oxidative processes are increased during prostate cancer and also that there is a reduction of antioxidant defenses in this pathology.
ISSN:1433-6510
DOI:10.7754/Clin.Lab.2014.131018