Hydrodynamic and aerosol modelling of the rapid expansion of supercritical solutions (RESS-process)

The rapid expansion of a supercritical solution (RESS-process) is modelled numerically to better understand the mechanisms of particle formation and growth. A model is presented which includes the expansion process inside the capillary nozzle as well as the post-expansion process with particle growt...

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Bibliographic Details
Published inThe Journal of supercritical fluids Vol. 26; no. 3; pp. 225 - 242
Main Authors Helfgen, B., Türk, M., Schaber, K.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.08.2003
Subjects
Griseofulvin
Micronization
RESS
Simulation
β-Sitosterol
Micronization
β-Sitosterol
Griseofulvin
Simulation
RESS
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Summary:The rapid expansion of a supercritical solution (RESS-process) is modelled numerically to better understand the mechanisms of particle formation and growth. A model is presented which includes the expansion process inside the capillary nozzle as well as the post-expansion process with particle growth inside the expansion chamber. Results are shown for the solid benzoic acid, griseofulvin and β-sitosterol in combination with the solvent carbon dioxide and trifluoromethane. The comparison with experimental results shows good agreement in general trends but does not yet match exactly with the measured mean particle sizes. Overall, a powerful tool for the optimisation of the RESS-process has been created which contributes to the understanding of the RESS-process.
ISSN:0896-8446
1872-8162
DOI:10.1016/S0896-8446(02)00159-6