Enantioselective reduction of prochiral ketones by chromium(II) complexes with amino acid ligands as the source of chirality

Prochiral ketones were reduced to enantiomerically enriched secondary alcohols by Cr(II)[ L-amino acid] complexes in good yields and moderate enantioselectivity. Reduction of prochiral ketones by Cr(II)[ L-amino acid] complexes in aqueous medium gives enantiomerically enriched alcohols.

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Bibliographic Details
Published inTetrahedron letters Vol. 40; no. 7; pp. 1373 - 1374
Main Authors Patonay, Tamás, Hajdu, Csongor, Jekő, József, Lévai, Albert, Micskei, Károly, Zucchi, Claudia
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 12.02.1999
Elsevier
Subjects
Amino acids
Chemistry
Chemistry, Organic
Chromans
Ketones
Physical Sciences
Reduction
Science & Technology
Amino acids
Reduction
Ketones
Chromans
ketones
reduction
HIYAMA
amino acids
chromans
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Summary:Prochiral ketones were reduced to enantiomerically enriched secondary alcohols by Cr(II)[ L-amino acid] complexes in good yields and moderate enantioselectivity. Reduction of prochiral ketones by Cr(II)[ L-amino acid] complexes in aqueous medium gives enantiomerically enriched alcohols.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)02611-2